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Article

A new Down syndrome rat model races forward.

Trends in genetics : TIG - 1 Nov 2022

Roper Randall J, Goodlett Charles R

Abstract excerpt

Animal models of Down syndrome (DS) provide an essential resource for understanding genetic, cellular, and molecular contributions to traits associated with trisomy 21 (Ts21). Recent genetic enhancements in the development of DS models, including the new TcHSA21rat model (Kazuki et al.), have potential to transform our understanding of and potential therapies for Ts21.

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Identifiers

PMID: 35581033
DOI: 10.1016/j.tig.2022.05.001
PMCID: PMC9561036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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