Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

14 Mar 2018

Abstract excerpt

Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is highly complex with constant features, such as mental retardation, dysmorphic traits and hypotonia, and variable features including heart defects, susceptibility to Alzheimer's disease (AD), type 2 diabetes, obesity and immune disorders. Overexpression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down syndrome and intellectual disability research
Share to Mitochondrial Function and Pathology
Share to Retinopathy of Prematurity Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30134785
DOI: 10.1186/s10020-018-0004-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targetsPMID 30134785Read ↗

Down syndrome is an oxidative phosphorylation disorderSemantic proximity Read ↗

Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome: Relevance to Aging and DementiaSemantic proximity Read ↗

Metformin restores the mitochondrial network and reverses mitochondrial dysfunction in Down syndrome cellsSemantic proximity Read ↗

Mitochondrial Dysfunction in Down Syndrome: From Pathology to TherapySemantic proximity Read ↗

Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome FetusesSemantic proximity Read ↗

Oxidative stress, thyroid dysfunction & Down syndromeSemantic proximity Read ↗

RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down SyndromeSemantic proximity Read ↗

Down syndrome--recent progress and future prospectsSemantic proximity Read ↗

Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain DysfunctionsSemantic proximity Read ↗

Proteomics Study of Peripheral Blood Mononuclear Cells in Down Syndrome ChildrenSemantic proximity Read ↗

Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways.Semantic proximity Read ↗

Mitochondrial dysfunction and Down's syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.