Article

Rogaratinib Suppresses Breast Cancer Invasion and Survival in a Microfluidic Tumor-on-Chip Model and Patient-Derived Organoids

2026-05-09

Abstract excerpt

<title>Abstract</title> <p>Purpose Fibroblast growth factor receptor (FGFR) signaling plays a critical role in breast cancer progression by promoting tumor cell proliferation, survival, and invasion, particularly under microenvironmental stimulation. However, conventional in vitro models inadequately reproduce the chemotactic gradients that regulate FGFR-driven invasion. This study aimed to evaluate the therapeu...

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Literature Corpus work: fcde2790-1572-5865-b201-b769c4aca1b8
DOI: 10.21203/rs.3.rs-9597983/v1

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