Article

Human Interleukin-4-Dependent Facilitation of Human IgG Production in PBL-NOG-hIL-4-Tg mice

2025-10-30

Abstract excerpt

Immune-humanized mice provide valuable experimental models for evaluating immune-based therapies, yet the induction of human antigen-specific IgG production remains limited due to species-specific incompatibilities. Our previous work demonstrated that NOG-hIL-4-Tg mice, which express human interleukin-4 (IL-4), support human T and B cell maintenance and enable antigen-specific IgG production following transplantat...

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Literature Corpus work: fcbd89e4-3e09-578a-8b6a-6b8778e69dd5
DOI: 10.1101/2025.10.29.685233

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