Article

Bacterial Hsp90 promotes virulence factor production through maintenance of NRPS megaenzymes

2025-07-01

Abstract excerpt

Pathogenic bacteria produce virulence factors critical to host infection. Here, we demonstrate the crucial role of the bacterial Hsp90 chaperone in the production of two major virulence factors, the colibactin genotoxin in Escherichia coli and the pyoverdine siderophore in Pseudomonas aeruginosa . Colibactin, a hybrid polyketide/non-ribosomal peptide (PK-NRP), and pyoverdine, a non-ribosomal peptide (NRP), are m...

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Literature Corpus work: fc8a59e3-77c6-5dde-b636-804366cb4beb
DOI: 10.1101/2025.07.01.662645

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