Article

Female cortical cellular mosaicism underlies shared MeCP2 and PCB impacted gene pathways

2025-06-01

Abstract excerpt

<h4>Summary</h4> Etiologies of neurodevelopmental disorders involve genes and environment however their interactions are understudied. Rett Syndrome (RTT) is an X-linked, dominant neurodevelopmental disorder caused by mutations in MECP2 , encoding the epigenetic regulator methyl CpG binding protein. Epigenetic features of MECP2 expression due to X-linked cellular mosaicism and the variability in severity and ti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc8759a4-261c-5f75-87cc-b55582ebac0a
DOI: 10.1101/2025.05.28.655836

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Female cortical cellular mosaicism underlies shared MeCP2 and PCB impacted gene pathwaysDOI 10.1101/2025.05.28.655836Read

Early transcriptional signatures of MeCP2 positive and negative cells in Rett syndromeSemantic proximity Read

Placental-brain axis in females detected within broadly impacted metabolic gene networks protects against prenatal PCB exposureSemantic proximity Read

Single-nucleus profiling reveals a core disease signature and cell type-specific vulnerabilities in early Rett syndrome.Semantic proximity Read

Rett syndrome – biological pathways leading from MECP2 to disorder phenotypesSemantic proximity Read

Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposureSemantic proximity Read

Rett syndrome and MeCP2: linking epigenetics and neuronal function.Semantic proximity Read

Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders.Semantic proximity Read

Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progressionSemantic proximity Read

Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression.Semantic proximity Read

Effects of Developmental Lead and Phthalate Exposures on DNA Methylation in Adult Mouse Blood, Brain, and Liver Identifies Tissue- and Sex-Specific Changes with Implications for Genomic ImprintingSemantic proximity Read

Methyl-CpG-binding protein 2 mediates overlapping mechanisms across brain disorders.Semantic proximity Read

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome.Semantic proximity Read