Disease Stage- and Risk-Associated RNA Editing Signatures in Acute Myeloid Leukemia and Their Utility for Peripheral Blood-Based Assessment

Abstract excerpt

RNA editing is a widespread post-transcriptional regulatory mechanism, but its role in acute myeloid leukemia (AML) remains incompletely understood. We analyzed RNA editing in 59 paired diagnosis-relapse AML samples and eight age-matched healthy controls using a stringent discovery pipeline and beta-binomial regression framework accounting for overdispersion and repeated measurements. A total of 166,323 high-confi...

Topics

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• Gene Expression Profiling
• Isocitrate Dehydrogenase
• Leukemia, Myeloid, Acute
• Machine Learning
• Neural Networks, Computer
• Prediction Algorithms
• Predictive Learning Models
• Transcriptome

Identifiers and source

Literature Corpus work

fc7e8187-5449-59f4-b3f1-de1deb05026a

DOI

10.64898/2026.06.29.735403