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Precision Detection of Rifampin-resistant rpoB L378R Mutation in Mycobacterium tuberculosis with CRISPR-Cas12a

2025-08-14

Abstract excerpt

<title>Abstract</title> <p>Rifampin is the most effective drug in the treatment of tuberculosis.However, certain strains of MTB have developed resistance to rifampin, leading to the need for alternative treatment options.The <italic>rpoB</italic> gene mutations play a central role in MTB resistance to the rifampin, so it is essential to identify these mutations and efficiently treat rifampin-resistant MTB strains...

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Literature Corpus work
fc7de4a7-bc47-52ae-bd5d-5b2223685790
DOI
10.21203/rs.3.rs-7257131/v1
Open publication

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Precision Detection of Rifampin-resistant rpoB L378R Mutation in Mycobacterium tuberculosis with CRISPR-Cas12aDOI 10.21203/rs.3.rs-7257131/v1
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