Article

Insights into the role of glycerophospholipids on the iron export function of SLC40A1 and the molecular mechanisms of ferroportin disease

2024-02-05

Abstract excerpt

<h4>ABSTRACT</h4> SLC40A1 is the sole iron export protein reported in mammals. In humans, its dysfunction is responsible for ferroportin disease, an inborn error of iron metabolism transmitted as an autosomal dominant trait and observed in different ethnic groups. As a member of the major facilitator superfamily, SLC40A1 requires a series of conformational changes to enable iron translocation across the plasma me...

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Literature Corpus work: 2ee1a842-a433-5a97-8b4a-e736ca831975
DOI: 10.1101/2024.02.05.578958

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