Article

Omicron evolution drives increased ciliated cell tropism and dysfunction in nasal epithelia

2025-11-20

Abstract excerpt

SARS-CoV-2 Omicron variants demonstrate greater replication efficiency in the upper respiratory tract than both ancestral virus and Delta variant, potentially due to stronger interactions with motile cilia in human nasal epithelial cells. Despite the emergence of numerous Omicron variants, there has been no comprehensive investigation comparing their interactions with ciliated cells. Here, we use differentiated pr...

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Literature Corpus work: 20a74b10-96bd-524f-925e-b08db51088e4
DOI: 10.1101/2025.11.19.689397

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