Article
Proteotranscriptomic classification and characterization of pancreatic neuroendocrine neoplasms.
Cell reports - 12 Oct 2021
Yang Kevin C, Kalloger Steve E, Aird John J, Lee Michael K C, Rushton Christopher, Mungall Karen L, Mungall Andrew J, Gao Dongxia, Chow Christine, Xu Jing, Karasinska Joanna M, Colborne Shane, Jones Steven J M, Schrader Jörg, Morin Ryan D, Loree Jonathan M, Marra Marco A, Renouf Daniel J, Morin Gregg B, Schaeffer David F, Gorski Sharon M
Abstract excerpt
Pancreatic neuroendocrine neoplasms (PNENs) are biologically and clinically heterogeneous. Here, we use a multi-omics approach to uncover the molecular factors underlying this heterogeneity. Transcriptomic analysis of 84 PNEN specimens, drawn from two cohorts, is substantiated with proteomic profiling and identifies four subgroups: Proliferative, PDX1-high, Alpha cell-like and Stromal/Mesenchymal. The...
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