Article

Integrative single-cell characterization of frugivory adaptations in the bat kidney and pancreas

2023-02-13

Abstract excerpt

Frugivory evolved multiple times in mammals, including bats. However, the cellular and molecular components driving it remain largely unknown. Here, we used integrative single-cell sequencing on insectivorous and frugivorous bat kidneys and pancreases and identified key cell population, gene expression and regulatory element differences associated with frugivorous adaptation that also relate to human disease, part...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fbe2cabd-7107-5fa1-8a03-56b85fb28b55
DOI: 10.1101/2023.02.12.528204

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative single-cell characterization of frugivory adaptations in the bat kidney and pancreasDOI 10.1101/2023.02.12.528204Read

It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and diseaseSemantic proximity Read

The Human Pancreas Cell Atlas defines a healthy reference framework for disease contextualization and translational benchmarkingSemantic proximity Read

A transcriptional cross species map of pancreatic islet cellsSemantic proximity Read

Spatial and functional mapping of the human pancreas reveals endocrine and exocrine cell states in health and metabolic diseaseSemantic proximity Read

Revealing the biological features of the axolotl pancreas as a new research modelSemantic proximity Read

Cross-species single-cell transcriptomic analysis reveals divergence of cell composition and functions in mammalian ileum epitheliumSemantic proximity Read

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progressionSemantic proximity Read

Interrogating islets in health and disease with single-cell technologiesSemantic proximity Read

A cell atlas of the fly kidneySemantic proximity Read

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population StructureSemantic proximity Read

Spatial and single-cell transcriptomics illuminate bat immunity and barrier tissue evolutionSemantic proximity Read

Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosisSemantic proximity Read