Article

Superantigen-driven polyfunctional CD4+ T follicular regulatory cells impair tonsillar plasmablast function and class-switched antibody production

2026-06-05

Abstract excerpt

<title>Abstract</title> Invasive <italic>Staphylococcus aureus</italic> infections have high mortality and reinfection rates, in part due to impaired development of enduring antibody-mediated immunity. The generation of pathogen-specific antibodies is typically orchestrated and counter-regulated by CD4 + T follicular helper (T FH ) and T follicular regulatory (T FR )...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fbdee5bb-c574-5544-9c61-fb5f76777137
DOI: 10.21203/rs.3.rs-9858212/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Superantigen-driven polyfunctional CD4+ T follicular regulatory cells impair tonsillar plasmablast function and class-switched antibody productionDOI 10.21203/rs.3.rs-9858212/v1Read

Streptococcal superantigen-induced expansion of human tonsil T cells leads to altered T follicular helper cell phenotype, B cell death, and reduced immunoglobulin releaseSemantic proximity Read

Evidence that recurrent Group A streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant Tfh cellsSemantic proximity Read

Recruitment of plasma cells to the bone marrow in primary and secondary immune reactionsSemantic proximity Read

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage functionSemantic proximity Read

Alterations in Germinal Center Formation and B Cell Activation during Severe Orientia tsutsugamushi Infection in MiceSemantic proximity Read

Induction of Human Regulatory T Cells with Bacterial Superantigens.Semantic proximity Read

The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cellsSemantic proximity Read

IL-1β Signalling Modulates T Follicular Helper and Regulatory Cells in Human Lymphoid TissuesSemantic proximity Read

Staphylococcal superantigens in colonization and diseaseSemantic proximity Read

Antibody Correlates of Resilience to Staphylococcus aureus Disease and Recurrence in ChildrenSemantic proximity Read

Manipulation of Innate and Adaptive Immunity by Staphylococcal SuperantigensSemantic proximity Read

B10 cell regulation of health and disease.Semantic proximity Read