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Association of Pathogenic/Likely Pathogenic Inherited Cardiomyopathy Variants With Heart Failure: A TOPMed Multiancestry Analysis.

Mayo Clinic proceedings - 1 Nov 2025

Shetty Naman S, Gaonkar Mokshad, Pampana Akhil, Patel Nirav, Carson April P, Haring Bernhard, Psaty Bruce M, Kooperberg Charles, Boerwinkle Eric, Rotter Jerome I, Lima João A C, Kizer Jorge R, Martin Lisa Warsinger, Taylor Kent D, Hall Michael E, Fornage Myriam, Shah Sanjiv J, Rich Stephen S, Vasan Ramachandran S, Nassir Rami, Li Peng, Arora Garima, Arora Pankaj

Abstract excerpt

OBJECTIVE: To evaluate the prevalence of pathogenic/likely pathogenic inherited cardiomyopathy variants and their association with heart failure in the (TOPMed) TransOmic for Precision of Medicine cohorts. METHODS: A retrospective cohort study using the TOPMed cohorts, including multi-ancestry US adults (≥18 years of age) with sequencing data, was conducted. Pathogenic/likely pathogenic inherited cardiomyopathy...

Topics

Humans
Heart Failure
Female
Male
Middle Aged
Retrospective Studies
Cardiomyopathies
United States
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Genetic Predisposition to Disease

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Identifiers

PMID: 40848024
DOI: 10.1016/j.mayocp.2025.01.021
PMCID: PMC12664333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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