Association of Common Ancestry-Enriched Variants With Cardiomyopathy and Arrhythmias.

doi:10.1161/CIRCULATIONAHA.126.080245

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Article

Association of Common Ancestry-Enriched Variants With Cardiomyopathy and Arrhythmias.

Circulation - 16 Jun 2026

Abe Temidayo A, Lancaster Megan C, Roden Dan M

Abstract excerpt

BACKGROUND: Individuals of African ancestry are underrepresented in genetic studies, contributing to disproportionately higher rates of variants of uncertain significance (VUS) and fewer actionable results in genetic testing for cardiomyopathies and arrhythmias. We aimed to determine whether ancestry-enriched VUS confer measurable cardiovascular risk among individuals of African ancestry. METHODS: We identified...

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PMID: 42200287
DOI: 10.1161/CIRCULATIONAHA.126.080245
PMCID: PMC13326729

Genes

PKP2
FLNC
ELAC2
SCN5A

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Association of Common Ancestry-Enriched Variants With Cardiomyopathy and Arrhythmias.

Abstract excerpt

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Variants

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