Article

Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model

2025-09-01

Abstract excerpt

I. <h4>ABSTRACT</h4> The R403Q mutation in the sarcomere protein beta-myosin heavy chain (β-MHC) is a known genetic cause of hypertrophic cardiomyopathy (HCM), associated with ventricular hypercontractility, impaired relaxation, and cardiac arrhythmias. Despite extensive research, the mutations impact on myosin contractile properties remains unclear, likely due, at least in part, to discrepancies cross different...

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Literature Corpus work: c9c9aec7-3cd9-53c8-9cd0-d929a1deb2b1
DOI: 10.1101/2025.08.27.672708

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