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Caloric restriction leading to attenuation of experimental Alzheimer's disease results from alterations in gut microbiome

1 Jul 2024

Abstract excerpt

BACKGROUND: Caloric restriction (CR) might be effective for alleviating/preventing Alzheimer's disease (AD), but the biological mechanisms remain unclear. In the current study, we explored whether CR caused an alteration of gut microbiome and resulted in the attenuation of cognitive impairment of AD animal model. METHODS: Thirty-week-old male APP/PS1 transgenic mice were used as AD models (AD mouse). CR was...

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PMID: 38992870
DOI: 10.1111/cns.14823

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