Article

Gut miRNA regulates gut microbiome and Alzheimer’s pathology in <i>App</i> -knock-in mice

2025-06-08

Abstract excerpt

Alzheimer’s disease (AD) alters the gut microbiome. It remains unclear whether manipulation of miRNA could modulate the gut microbiome and AD pathologies. Depletion of gut miRNA in App -knock-in mice by conditional knockout of Dicer1 gene in intestinal epithelial cells: 1) decreased the absolute number and changed the composition of bacteria in both the gut and brain; 2) reduced cerebral Aβ load by inhibiting β-...

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Literature Corpus work: 1945a8cc-f98c-5cd7-a799-cc2c75897a39
DOI: 10.1101/2025.06.05.658056

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