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Article

Small-molecule inhibitors of Slack potassium channels as potential therapeutics for childhood epilepsies.

Pharmaceutical patent analyst - 1 Mar 2022

M Qunies Alshaima'a, A Emmitte Kyle

Abstract excerpt

Slack channels are sodium-activated potassium channels that are encoded by the KCNT1 gene. Several KCNT1 gain of function mutations have been linked to malignant migrating partial seizures of infancy. Quinidine is an anti-arrhythmic drug that functions as a moderately potent inhibitor of Slack channels; however, quinidine use is limited by its poor selectivity, safety and pharmacokinetic profile. Slack channels...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35369761
DOI: 10.4155/ppa-2022-0002
PMCID: PMC9260495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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