Article

Quantitative analyses of single mitochondrial structure-function heterogeneity uncovers stemness specification by redox-tuned small-mitochondrial-networks

2024-12-26

Abstract excerpt

Lack of quantitative understanding of the marked heterogeneity of multifaceted mitochondria poses challenges in unraveling their translatable role. Here, we hierarchically untangled multilevel heterogeneity of mitochondrial networks and non-networks by simultaneously analysing their structure-function within single components and their units, in cells and tissues. Such mito-SinComp quantitative analyses revealed t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b420b7cf-aa3d-587c-94c9-825c3d76b03d
DOI: 10.1101/2024.12.26.630414

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantitative analyses of single mitochondrial structure-function heterogeneity uncovers stemness specification by redox-tuned small-mitochondrial-networksDOI 10.1101/2024.12.26.630414Read

Immune system cells from COVID-19 patients display compromised mitochondrial-nuclear expression co-regulation and rewiring toward glycolysisSemantic proximity Read

Cooperative Architecture of Mitochondrial Proteome HomeostasisSemantic proximity Read

Filtering cells with high mitochondrial content depletes viable metabolically altered malignant cell populations in cancer single-cell studiesSemantic proximity Read

mitoXplorer 3.0, a web tool for exploring mitochondrial dynamics in single-cell RNA-seq dataSemantic proximity Read

From Plants to Patients: Mitochondrial Stress Signaling as a Systems Framework for Human Disease VulnerabilitySemantic proximity Read

Mitonuclear Communication in Stem Cell FunctionSemantic proximity Read

MitoPerturb-Seq identifies common and gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmySemantic proximity Read

Mitotyping – An integrative framework to quantify mitochondrial specialization and plasticitySemantic proximity Read

Eukaryotic Mitogenomes and Their Key Insights: Architecture, Evolution and Mitonuclear CoevolutionSemantic proximity Read

Mitochondrial DNA Density Homeostasis Accounts for the Threshold Effect in Human Mitochondrial DiseaseSemantic proximity Read

Mitochondrial DNA density homeostasis accounts for a threshold effect in a cybrid model of a human mitochondrial disease.Semantic proximity Read

Cell-attribute aware community detection improves differential abundance testing from single-cell RNA-Seq dataSemantic proximity Read