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Postpartum estrogen withdrawal induces deficits in affective behaviors and increases ΔFosB in D1 and D2 neurons in the nucleus accumbens core in mice

2022-09-08

Abstract excerpt

In placental mammals, estradiol levels are chronically elevated during pregnancy, but quickly drop to prepartum levels following birth. This may produce an “estrogen withdrawal” state that has been linked to changes in affective states in humans and rodents during the postpartum period. The neural mechanisms underlying these affective changes, however, are understudied. We used a hormone-simulated pseudopregnancy...

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Literature Corpus work
fafad90b-98fb-5682-b945-cd0bb96bc602
DOI
10.1101/2022.09.08.505352
Open publication

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Postpartum estrogen withdrawal induces deficits in affective behaviors and increases ΔFosB in D1 and D2 neurons in the nucleus accumbens core in miceDOI 10.1101/2022.09.08.505352
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