Article

Whole transcriptome in-silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects

2020-04-21

Abstract excerpt

<title>Abstract</title> <p>BACKGROUND Stroke/thromboembolic events, infections and death are all significantly increased by antipsychotics in dementia but little is known about why they can be harmful. Using a novel application of a drug repurposing paradigm, we aimed to identify potential mechanisms underlying adverse events. METHODS Whole transcriptome signatures were generated for SH-SY5Y cells treated with...

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Literature Corpus work: fad0d901-a7fd-55b5-90b9-2a0727ab6095
DOI: 10.21203/rs.3.rs-23545/v1

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