Article

Whole transcriptome <i>in-silico</i> screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side-effects

2020-04-09

Abstract excerpt

<h4>INTRODUCTION</h4> Stroke/thromboembolic events, infections and death are all significantly increased by antipsychotics in dementia but little is known about why they can be harmful. Using a novel application of a drug repurposing paradigm, we aimed to identify potential mechanisms underlying adverse events. <h4>METHOD</h4> Whole transcriptome signatures were generated for SH-SY5Y cells treated with amisulpri...

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Literature Corpus work: 3ae6aade-fbe7-5bf3-a510-771f04cb073c
DOI: 10.1101/2020.04.09.033472

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