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Harnessing hydrodynamics for high-yield production of extracellular vesicles from stem cells spheroids with specific cargo profiling

2025-01-03

Abstract excerpt

<h4>ABSTRACT</h4> This study presents a novel method and device for the hydrodynamic production of extracellular vesicles (EVs) derived from biomimetic multicellular 3D spheroids, enabling high-throughput particle release that is 10 to 20 times higher than in non-stimulated conditions. The device facilitates the formation of spheroids from human mesenchymal stem cells (hMSCs), offering an all-in-one approach for...

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Identifiers and source

Literature Corpus work
1fb6621c-c6db-5ffa-ac76-3180029a838c
DOI
10.1101/2025.01.02.631101
Open publication

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Harnessing hydrodynamics for high-yield production of extracellular vesicles from stem cells spheroids with specific cargo profilingDOI 10.1101/2025.01.02.631101
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