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Resistance, heteroresistance and fitness costs drive colistin treatment failure during <i>Acinetobacter baumannii</i> pneumonia

2025-07-24

Abstract excerpt

Acinetobacter baumannii is an ESKAPE pathogen linked to healthcare-associated diseases. Due to evolved resistance, last-resort antibiotics such as the lipooligosaccharide (LOS)-targeting colistin are increasingly used to treat multidrug-resistant isolates. To track the evolution of colistin resistance within a host, we performed sequential oropharyngeal infections in immunocompetent or immune-depleted mice in the...

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Literature Corpus work
fa90e73e-9533-5611-9f86-c7bd596684a7
DOI
10.1101/2025.07.24.666669
Open publication

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Resistance, heteroresistance and fitness costs drive colistin treatment failure during <i>Acinetobacter baumannii</i> pneumoniaDOI 10.1101/2025.07.24.666669
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