Article

Immunosuppression broadens evolutionary pathways to treatment failure during <i>Acinetobacter baumannii</i> pneumonia

2021-04-09

Abstract excerpt

Acinetobacter baumannii is increasingly refractory to antibiotic treatment in healthcare settings. As is true of most human pathogens, the genetic path to antimicrobial resistance (AMR) and the role that the immune system plays in modulating AMR during disease are poorly understood. Here we reproduced several routes to fluoroquinolone resistance, performing evolution experiments using sequential lung infections in...

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Literature Corpus work: 50b3acd1-53bc-5fea-b9ba-9b2430f4ebd1
DOI: 10.1101/2021.04.07.438861

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