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Article

Resistance, heteroresistance, and fitness costs drive colistin treatment failure during Acinetobacter baumannii pneumonia.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2026

Hernandez-Bird Juan, He Bixi, VanOtterloo Leah M, Billings Elizabeth B, Huo Wenwen, Teodoro Gabriella I C, Echlin Haley, Rosch Jason M, Trent M Stephen, Isberg Ralph R

Abstract excerpt

Acinetobacter baumannii is an Enterococcus, Staphylococcus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter species (ESKAPE) pathogen linked to healthcare-associated diseases. Due to evolved resistance, last-resort antibiotics such as the lipooligosaccharide (LOS)-targeting colistin are increasingly used to treat multidrug-resistant isolates. To track the evolution of colistin resistance within a host,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41461032
DOI: 10.1073/pnas.2515303123
PMCID: PMC12773716

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