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Article

C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.

Autophagy - 1 Sept 2020

Shao Qiang, Yang Mei, Liang Chen, Ma Li, Zhang Wei, Jiang Zhiwen, Luo Jun, Lee Jae-Kyung, Liang Chengyu, Chen Jian-Fu

Abstract excerpt

How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in C9orf72 is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex. Here we found that c9orf72 and smcr8 double-knockout (dKO) mice exhibit similar but more severe immune...

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Identifiers

PMID: 31847700
DOI: 10.1080/15548627.2019.1703353
PMCID: PMC8386604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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