Flavivirus reverse genetic systems, construction techniques and applications: A historical perspective

doi:10.1016/j.antiviral.2014.12.007

Article

Flavivirus reverse genetic systems, construction techniques and applications: A historical perspective

12 Dec 2014

Abstract excerpt

The study of flaviviruses, which cause some of the most important emerging tropical and sub-tropical human arbovirus diseases, has greatly benefited from the use of reverse genetic systems since its first development for yellow fever virus in 1989. Reverse genetics technology has completely revolutionized the study of these viruses, making it possible to manipulate their genomes and evaluate the direct effects of...

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