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Alphaviruses: Semliki Forest Virus and Sindbis Virus Vectors for Gene Transfer into Neurons

1 Oct 2011

Abstract excerpt

Alphaviral vectors based on Semliki Forest virus and Sindbis virus infect many host cell types, causing rapid and high-level transgene expression. In the CNS, Semliki Forest virus and Sindbis virus exhibit an outstanding preference for neurons rather than glial cells, compared to other viruses. Generation of high-titer virus stocks is rapid (less than two days) and typically requires biosafety level 1 or 2...

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PMID: 21971849
DOI: 10.1002/0471142301.ns0422s57

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