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Development of a network formation assay for developmental neurotoxicity hazard screening using 3D human iPSC derived BrainSpheres

2025-06-07

Abstract excerpt

Exposure of the developing brain to environmental neurotoxicants can result in permanent alterations in structure and/or function. To investigate the effects of chemical exposures on neurodevelopment, the human induced-pluripotent stem cell (iPSC)-derived neural BrainSphere model has been utilized due to its ability to form mature neuronal populations and exhibit spontaneous electrical activity. To model network f...

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Literature Corpus work
fa484af3-7144-55ae-b4fa-85dbcc777776
DOI
10.1101/2025.06.03.657699
Open publication

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Development of a network formation assay for developmental neurotoxicity hazard screening using 3D human iPSC derived BrainSpheresDOI 10.1101/2025.06.03.657699
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