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Article

Novel in vitro assay to investigate radiation induced changes in the functionality of human embryonic stem cell-derived neurospheres.

Neurotoxicology - 1 Jul 2020

Mayer Margot, Arrizabalaga Onetsine, Ciba Manuel, Schroeder Insa S, Ritter Sylvia, Thielemann Christiane

Abstract excerpt

Ionizing radiation (IR) is increasingly used for diagnostics and therapy of severe brain diseases. However, IR also has adverse effects on the healthy brain tissue, particularly on the neuronal network. This is true for adults but even more pronounced in the developing brain of unborn and pediatric patients. Epidemiological studies on children receiving radiotherapy showed an increased risk for cognitive decline...

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Identifiers

PMID: 32320710
DOI: 10.1016/j.neuro.2020.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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