Article

Phenotypic models of drug-drug-gene interactions mediated by cytochrome drug-metabolizing enzymes

2023-11-03

Abstract excerpt

Genetic polymorphisms in drug metabolizing enzymes and drug-drug interactions are major sources of inadequate drug exposure and ensuing adverse effects or insufficient responses. The current challenge in assessing drug-drug gene interactions (DDGI) for the development of precise dose adjustment recommendation systems is to take into account both simultaneously. Here, we analyze the static models of DDGI from in vi...

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Literature Corpus work: fa3780e3-cea7-55a5-853b-799aaf4ddbdf
DOI: 10.1101/2023.11.02.23297749

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