Article

The Predictive and Prognostic Value of T- and B-cell Transcriptomic Signatures for Clinical Response to Immune Checkpoint Blockade in Pleural Mesothelioma

2025-05-13

Abstract excerpt

<h4>Background</h4> Malignant pleural mesothelioma (PM) is an aggressive cancer with limited treatment options. Although immune checkpoint blockade (ICB) with nivolumab plus ipilimumab improves overall survival and has become standard-of-care, responses are variable and there are no predictive biomarkers for treatment outcome among PM patients with epithelioid histology. <h4>Methods</h4> We developed an eight-gene...

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Literature Corpus work: fa135507-737f-5993-91fb-ab7b9dc16f76
DOI: 10.1101/2025.05.12.25326806

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