Article

Using mitoribosomal profiling to investigate human mitochondrial translation

2018-01-29

Abstract excerpt

<h4>Background: </h4> : Gene expression in human mitochondria has various idiosyncratic features. One of these was recently revealed as the unprecedented recruitment of a mitochondrially-encoded tRNA as a structural component of the large mitoribosomal subunit. In porcine particles this is mt-tRNA Phe whilst in humans it is mt-tRNA Val . We have previously shown that when a mutation in mt-tRNA Val causes very l...

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Literature Corpus work: fa11cc44-2d5d-5815-932c-19b74f79b697
DOI: 10.12688/wellcomeopenres.13119.2

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