Article
Genetic variability in proteoglycan biosynthetic genes reveals new facets of heparan sulfate diversity.
Essays in biochemistry - 4 Dec 2024
Ouidja Mohand Ouidir, Biard Denis S F, Huynh Minh Bao, Laffray Xavier, Gomez-Henao Wilton, Chantepie Sandrine, Le Douaron Gael, Rebergue Nicolas, Maïza Auriane, Merrick Heloise, De Lichy Aubert, Dady Alwyn, González-Velasco Oscar, Rubio Karla, Barreto Guillermo, Baranger Kévin, Cormier-Daire Valerie, De Las Rivas Javier, Fernig David G, Papy-Garcia Dulce
Abstract excerpt
Heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans (PG) consist of a core protein to which the glycosaminoglycan (GAG) chains, HS or CS, are attached through a common linker tetrasaccharide. In the extracellular space, they are involved in the regulation of cell communication, assuring development and homeostasis. The HSPG biosynthetic pathway has documented 51 genes, with many diseases associated to...
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