Article

Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma

2026-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Primary mitochondrial diseases (PMD) have limited disease-modifying therapies, currently applicable to only 3 of over 400 discrete gene disorders. Cycloheximide (CHX) is a global cytosolic translation inhibitor we previously reported to rescue PMD preclinical models, although its toxicity precluded clinical development. To identify specific mediators underlying CHX treatment benefit in PMD, SOMA...

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Literature Corpus work: f9faedc0-d910-5fea-8198-fc6e9f35685f
DOI: 10.64898/2026.07.20.739625

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