Article

The squamous cell carcinoma antigen/SERPINB3 protects cervical cancer cells from chemoradiation by preventing lysoptosis

2021-02-19

Abstract excerpt

<title>Abstract</title> <p>The endogenous lysosomal cysteine protease inhibitor SERPINB3 (squamous cell carcinoma antigen 1, SCCA1) is elevated in patients with cervical cancer and other malignancies. High serum SERPINB3 is prognostic for recurrence and death following chemoradiation therapy (CRT). Cervical cancer cells genetically lacking <italic>SERPINB3</italic> are more sensitive to ionizing radiation (IR), s...

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Literature Corpus work: f9ecf7ec-81b4-5aae-85d2-5a8ea825d5d2
DOI: 10.21203/rs.3.rs-228819/v1

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