Article

An integrative systems biology and experimental approach identifies convergence of epithelial plasticity, metabolism, and autophagy to promote chemoresistance

2018-07-10

Abstract excerpt

The evolution of therapeutic resistance is a major cause of death for patients with solid tumors. The development of therapy resistance is shaped by the ecological dynamics within the tumor microenvironment and the selective pressure induced by the host immune system. These ecological and selective forces often lead to evolutionary convergence on one or more pathways or hallmarks that drive progression. These hall...

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Literature Corpus work: bab1e001-9f87-5d17-b0e8-5e432cff4f5c
DOI: 10.1101/365833

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