Article

Transthyretin-stabilizing mutation T119M is not associated with protection against vascular disease or death in the UK Biobank

2019-09-21

Abstract excerpt

<h4>Background</h4> Destabilized transthyretin (TTR) can result in the progressive, fatal disease transthyretin-mediated (ATTR) amyloidosis. A stabilizing TTR mutation, T119M, is the basis for a therapeutic strategy to reduce destabilized TTR. Recently, T119M was associated with extended lifespan and lower risk of cerebrovascular disease in a Danish cohort. We aimed to determine whether this finding could be rep...

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Literature Corpus work: f9c377fa-ca69-5ba7-afbd-e8e3ae6fa235
DOI: 10.1101/771626

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