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Article

Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution.

Journal of molecular biology - 2 Mar 2001

Sebastião M P, Lamzin V, Saraiva M J, Damas A M

Abstract excerpt

Transthyretin (TTR) amyloidosis is a conformational disturbance, which, like other amyloidoses, represents a life threat. Here, we report a TTR variant, TTR Thr119Met, that has been shown to have a protective role in the development of clinical symptoms in carriers of TTR Val30Met, one of the most frequent variants among TTR amyloidosis patients. In order to understand this effect, we have determined the...

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Source

Identifiers

PMID: 11243784
DOI: 10.1006/jmbi.2000.4415

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transthyretin stability as a key factor in amyloidogenesis: X-ray analysis at atomic resolution.PMID 11243784Read ↗

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From molecular variant to disease: initial steps in evaluating the association of transthyretin M119 with disease.Semantic proximity Read ↗

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