From molecular variant to disease: initial steps in evaluating the association of transthyretin M119 with disease.

Article

From molecular variant to disease: initial steps in evaluating the association of transthyretin M119 with disease.

American journal of human genetics - 1 Jan 1992

Ii S, Sobell J L, Sommer S S

Abstract excerpt

Traditionally, clinical research has sought to determine the molecular basis of clinical signs and symptoms. Increasingly, the traditional process will be reversed, as many structural protein variants are elucidated as a result of powerful PCR-based methods. Herein we describe a variant of transt...

Topics

Base Sequence
Haplotypes
Heterozygote
Homozygote
Humans
Methionine
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Prealbumin
Threonine

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.