Article

<i>In situ</i> single-cell analysis of canonical breast cancer biomarkers: phenotypic heterogeneity and implications on response to HER2 targeting agents

2022-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer is a heterogeneous disease. Tumor cells and the surrounding microenvironment form an ecosystem that determine disease progression and response to therapy. To characterize the breast cancer ecosystem and the changes induced by targeted treatment selective pressure, we analyzed 136 HER2-positive tumor samples for the expression of canonical BC tumor diagnostic proteins at a single ce...

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Literature Corpus work: f9c21932-72d1-548a-9538-2064fda7e868
DOI: 10.1101/2022.09.21.508826

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