Article

Multiomic dissection of HR <sup>+</sup> /HER2 <sup>−</sup> invasive lobular breast carcinoma reveals mobilized yet dysfunctional anti-tumor immunity shaped by tumor-stroma crosstalk and impaired antigen presentation

2026-05-29

Abstract excerpt

<h4>Context</h4> Immunotherapy based on immune checkpoint inhibitors (ICI) revolutionized the treatment of triple-negative (TN) breast carcinomas (BC), but remains more challenging in HR + /HER2 - BCs. Because invasive lobular carcinomas (ILC) generally exhibit low immune infiltration, ICIs were largely overlooked in this pathological type. The only clinical trial of ICIs dedicated to ILCs showed disappointing...

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Literature Corpus work: 117bbe5c-4919-5f1c-b46c-2f039d8a89d0
DOI: 10.64898/2026.05.28.728418

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Multiomic dissection of HR <sup>+</sup> /HER2 <sup>−</sup> invasive lobular breast carcinoma reveals mobilized yet dysfunctional anti-tumor immunity shaped by tumor-stroma crosstalk and impaired antigen presentationDOI 10.64898/2026.05.28.728418Read

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