Article

Targeting Nitric Oxide Synthase 2 Reverses Learning Deficits in an Oligodendrocyte-Focused Model of Costello Syndrome

2026-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Myelination of axons by oligodendrocytes (OLs) greatly improves information processing in the brain; consequently, compromised myelin negatively impacts brain function. Young-adult Costello Syndrome (CS) patients present with learning disabilities and regression of psychomotor skills in correlation with abnormal brain white matter, delayed myelination, and dysmyelination. This suggests the invol...

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Literature Corpus work: f9bbd519-8ef9-518e-aecf-0cfcc671850e
DOI: 10.64898/2026.06.01.729333

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