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Article

Generation of human induced pluripotent stem cell lines from a patient with OTOF-related deafness and a carrier relative.

Stem cell research - 1 Aug 2026

Yu Meirong, Huang Yangyiyi, Lin Pengfang, Liu Amin, Wang Yunxiu, Chen Jia, Jiang Hua, Chen Chao, Liu Xiao

Abstract excerpt

OTOF-related deafness (DFNB9) is an auditory neuropathy caused by mutations in the OTOF gene, disrupting synaptic transmission in the inner ear. We generated two human induced pluripotent stem cell (iPSC) lines using transgene-free episomal reprogramming: ZEENTi001-A from a patient with compound heterozygous OTOF mutations (c.2122C > T and c.5197G > A) and ZEENTi002-A from a heterozygous carrier. Both lines...

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Identifiers

PMID: 42000544
DOI: 10.1016/j.scr.2026.103988

Genes

OTOF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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