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<i>In vivo</i> -directed evolution identifies AAV-WM04 as a next-generation vector for potent and durable hearing restoration in DFNB9

2026-03-11

Abstract excerpt

Efficient and cell-specific gene delivery to cochlear inner hair cells (IHCs) remains a major challenge for inner ear gene therapy. Here, we identify and characterize a novel AAV2-derived capsid, AAV-WM04, that enables highly efficient and selective IHC transduction at low doses. Using an in vivo –directed evolution strategy, we generated a randomized AAV2 capsid library with 9–amino acid insertions and performed...

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Literature Corpus work
900d32a4-2398-5db2-a2e3-ad3a476dbaf0
DOI
10.64898/2026.03.11.710960
Open publication

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