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Regenerating hair cells in vestibular sensory epithelia from humans

18 Jul 2018

Abstract excerpt

Human vestibular sensory epithelia in explant culture were incubated in gentamicin to ablate hair cells. Subsequent transduction of supporting cells with ATOH1 using an Ad-2 viral vector resulted in generation of highly significant numbers of cells expressing the hair cell marker protein myosin VIIa. Cells expressing myosin VIIa were also generated after blocking the Notch signalling pathway with TAPI-1 but less...

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Share to Ear Surgery and Otitis Media
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PMID: 30019672
DOI: 10.7554/elife.34817

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