Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

Abstract excerpt

INTRODUCTION: Chimeric antigen receptor (CAR) T-cell therapy is a promising and innovative cancer therapy. However, immunosuppressive tumor microenvironments (TME) limit T cell persistence and durable efficacy. Here, we aimed to identify and target immunosuppressive factors in the TME of neuroblastoma, a pediatric extracranial solid tumor, to improve CAR-T efficacy. METHODS: Immunosuppressive factors were...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to CAR-T cell therapy research
• Share to Macrophage Migration Inhibitory Factor
• Share to Signaling Pathways in Disease