Article

Highly multiplexed imaging recovers immune and metabolic niches in multiple myeloma associated with disease progression and bone involvement

2025-09-12

Abstract excerpt

Multiple myeloma (MM) is a cancer arising from genetically aberrant plasma cells (PCs) that remain dependent on the bone marrow (BM) microenvironment for disease establishment and progression. Here, we spatially mapped BM biopsies from patients with MM, smoldering MM and monoclonal gammopathy of undetermined significance by imaging mass cytometry. We found that PCs near bone surfaces were quiescent and demonstrate...

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Literature Corpus work: f961399f-a1c4-5eed-a8ca-cf038265b5da
DOI: 10.1101/2025.09.08.674473

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